Study of Ion Transfer Coupling with Electron Transfer by Hydrophilic Droplet Electrodes

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• 作者：Jing Gu ; Wenbo Zhao ; Ye Chen ; Xin Zhang ; Xiang Xie ; Shujuan Liu ; Xiaofeng Wu ; Zhiwei Zhu ; Meixian Li ; Yuanhua Shao
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：December 1, 2015
• 年：2015
• 卷：87
• 期：23
• 页码：11819-11825
• 全文大小：442K
• ISSN：1520-6882

文摘

In a hydrophilic droplet three-electrode system, electroactive species within the droplet play very important roles in the electron-transfer (ET) process on the solid/electrolyte interface, which can then induce an ion-transfer (IT) reaction at the liquid/liquid interface. In this work, several redox couples and electroactive species are chosen to study ET鈥揑T coupling processes at the water/1,2-dichloroethane (W/DCE) interface by cyclic voltammetry (CV) and Osteryoung square wave voltammetry (OSWV). Among them, the redox couple Ru(NH₃)₆^3+/2+ has been found to have the widest useful potential window of about 1.2 V. A hydrophilic droplet three-electrode system using a single electroactive molecule instead of a redox couple has been confirmed to be stable and has similar functionality to a redox couple. In addition, the lipophilicity of antiplatelet drug clopidogrel at the W/DCE interface is investigated and its ionic partition diagram has been constructed. Protonated clopidogrel is detected in a linear concentration range of 5.0鈥?0 渭M and the limit of detection (LOD) is calculated to be 3.0 渭M by using the hydrophilic droplet system Ru(NH₃)₆^3+/2+ and OSWV.