Palladium-Catalyzed Intramolecular Dearomatization of Indoles via Decarboxylative Alkynyl Termination
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- 作者：Si Chen ; Xin-Xing Wu ; Jia Wang ; Xin-Hua Hao ; Yu Xia ; Yi Shen ; Huanwang Jing ; Yong-Min Liang
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：August 19, 2016
- 年：2016
- 卷：18
- 期：16
- 页码：4016-4019
- 全文大小：432K
- 年卷期：0
- ISSN：1523-7052
文摘
A highly diastereoselective dearomatization of indoles via palladium-catalyzed decarboxylative alkynyl termination was developed. This protocol provides dissimilar tetracyclic and tetrasubstituted indoline scaffolds bearing congested stereocenters, which led to operationally simple conditions, short time, and broad substrate scope. Additionally, this reaction system could be scaled to gram quantities in a satisfactory yield and diastereoselectivity.