Palladium-Catalyzed Tandem Intramolecular Oxy/Amino-Palladation/Isocyanide Insertion: Synthesis of 伪-Benzofuranyl/Indolylacetamides
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- 作者：Nuligonda Thirupathi ; Madala Hari Babu ; Vikas Dwivedi ; Ruchir Kant ; Maddi Sridhar Reddy
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：June 6, 2014
- 年：2014
- 卷：16
- 期：11
- 页码：2908-2911
- 全文大小：402K
- 年卷期：v.16,no.11(June 6, 2014)
- ISSN：1523-7052
文摘
A novel palladium-catalyzed approach to 2-benzofuranyl/indolylacetamides from 1-(o-hydroxy/aminophenyl)propargylic alcohols and isocyanides is described. The reaction proceeds through a cascade that includes oxy/aminopalladation, isocyanide insertion, and 1,4-hydroxyl migration. No oxidant or ligand is needed to promote the cascade, and the reactions are carried out under mild conditions to afford the products through high functional tolerance.