Cholesterol-Lowering Activity of Soy-Derived Glyceollins in the Golden Syrian Hamster Model
详细信息 查看全文
- 作者：Haiqiu Huang ; Zhuohong Xie ; Stephen M. Boue ; Deepak Bhatnagar ; Wallace Yokoyama ; Liangli (Lucy) Yu ; Thomas T. Y. Wang
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2013
- 出版时间：June 19, 2013
- 年：2013
- 卷：61
- 期：24
- 页码：5772-5782
- 全文大小：771K
- 年卷期：v.61,no.24(June 19, 2013)
- ISSN：1520-5118
文摘
Hypercholesterolemia is one of the major factors contributing to the risk of cardiovascular disease (CVD), which is the leading cause of death in developed countries. Consumption of soy foods has been recognized to lower the risk of CVD, and phytochemicals in soy are believed to contribute to the health benefits. Glyceollin is one of the candidate phytochemicals synthesized in stressed soy that may account for many unique biological activities. In this study, the in vivo cholesterol-lowering effect of glyceollins was investigated. Male golden Syrian hamsters were fed diets including (1) 36 kcal% fat diet, (2) 36 kcal% fat diet containing 250 mg/kg diet glyceollins, or (3) chow for 28 days. Hepatic cholesterol esters and free cholesterol, hepatic total lipid content, plasma lipoproteins, fecal bile acid, fecal total cholesterol, and cholesterol metabolism related gene expressions were measured. Glyceollin supplementation led to significant reduction of plasma VLDL, hepatic cholesterol esters, and total lipid content. Consistent with changes in circulating cholesterol, glyceollin supplementation also altered expression of the genes related to cholesterol metabolism in the liver. In contrast, no change in plasma LDL and HDL, fecal bile acid, or cholesterol content was observed. The cholesterol-lowering effect of glyceollins appeared not to go through the increase of bile excretion. These results supported glyceollins鈥?role as novel soy-derived cholesterol-lowering phytochemicals that may contribute to soy鈥檚 health effects.