Bubble-in-Bubble Strategy for High-Quality Ultrasound Imaging with a Structure Coupling Effect

详细信息    查看全文

• 作者：Peng Yang ; Fangyuan Zhao ; Jing Ding ; Jia Guo ; Weibin Shi ; Changchun Wang ; Xinhua Hu
• 刊名：Chemistry of Materials
• 出版年：2014
• 出版时间：March 25, 2014
• 年：2014
• 卷：26
• 期：6
• 页码：2121-2127
• 全文大小：471K
• 年卷期：v.26,no.6(March 25, 2014)
• ISSN：1520-5002

文摘

We design and synthesize monodisperse multi-layer microbubbles (MLBs) with bubble-in-bubble structure using the polymer-backbone-transition method (PBTM). Besides the tunable layer number and microbubble size, we can accurately control the layer-to-layer space and the thickness of each layer. In comparison to traditional single-layer microbubbles, the MLBs can be used as a novel promising model of contrast agent for high-performance ultrasound imaging. The ultrasound signal of MLBs shows a strong structure coupling effect; as the number of layer increases, both the backscatter signal and lifespan increase significantly. We apply a classical acoustic theory to calculate the ultrasound scattering cross-section for the bubbles. It is found that the MLBs exhibit a larger ultrasound scattering cross-section than single-layer bubbles with the same size under certain experimental conditions. Such theoretical results agree well with the ultrasound experimental results.