Meroterpenoids with New Skeletons from Myrtus communis and Structure Revision of Myrtucommulone K
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- 作者：Chao Liu ; Song Ang ; Xiao-Jun Huang ; Hai-Yan Tian ; Yuan-Yuan Deng ; Dong-Mei Zhang ; Ying Wang ; Wen-Cai Ye ; Lei Wang
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：August 19, 2016
- 年：2016
- 卷：18
- 期：16
- 页码：4004-4007
- 全文大小：371K
- 年卷期：0
- ISSN：1523-7052
文摘
Five sesquiterpene-based meroterpenoids with three kinds of new skeletons [1, 2, 3, (+)-4, and (−)-4] were isolated from the leaves of Myrtus communis. Compound 1 featured a new carbon skeleton with an unprecedented octahydrospiro[bicyclo[7.2.0]undecane-2,2′-chromene] tetracyclic ring system, which possessed two preferred conformations detected by variable-temperature NMR spectroscopy experiments. In addition, the structure of reported myrtucommulone K was revised to be compound 3. The plausible biosynthetic pathways of these meroterpenoids and their cytotoxicities are discussed.