Improving the Yield of Mono-DNA-Functionalized Gold Nanoparticles through Dual Steric Hindrance
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- 作者：Zhengtao Li ; Enjun Cheng ; Wenxiao Huang ; Tao Zhang ; Zhongqiang Yang ; Dongsheng Liu ; Zhiyong Tang
- 刊名：Journal of the American Chemical Society
- 出版年：2011
- 出版时间：October 5, 2011
- 年：2011
- 卷：133
- 期：39
- 页码：15284-15287
- 全文大小：770K
- 年卷期：v.133,no.39(October 5, 2011)
- ISSN：1520-5126
文摘
A novel strategy of dual steric hindrance, which was obtained by Janus modification of gold nanoparticles (Au NPs) and volume exclusion of DNA, was adopted to prepare mono-DNA-modified Au NPs. The yield of mono-DNA-functionalized Au NPs significantly improved from 44 to 70% in the reaction between Au NPs and thiolated DNA. Furthermore, the specificity of mono-DNA-functionalized Au NPs was enhanced from 57 to 95%. The as-prepared Au NPs without postsynthetic treatment showed good controllability in self-assembly fabrication of complex nanostructures.