The Estimation of Field-Dependent Conductance Change of Nanopore by Field-Induced Charge in the Translocations of AuNPs-DNA Conjugates

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• 作者：Hongwen Wu ; Hang Liu ; Shengwei Tan ; Jingjing Yu ; Wenyuan Zhao ; Lei Wang ; Quanjun Liu
• 刊名：Journal of Physical Chemistry C
• 出版年：2014
• 出版时间：November 20, 2014
• 年：2014
• 卷：118
• 期：46
• 页码：26825-26835
• 全文大小：604K
• ISSN：1932-7455

文摘

Solid-state nanopores have been proven to be a powerful tool for the characterization of individual molecules and nanoparticles. The basic motivation of this technique is to determine the particle size by the conductance change during the translocation of the particle. However, there still has not been a quantitative estimation of the dependence of electric field on the conductance change due to a particle translocation. Here, we present the first observations of the intriguing biphasic and asymmetrical events in the translocations of DNA-modified gold nanoparticles through 鈭?0 nm nanopores. An electric field-dependent conductance change and quadratic nonlinear electrophoresis were observed as well. Thus, we develop an approximation of the conductance change of nanopore based on induced-charge electrophoresis. The effects of salt concentration, the applied voltage, and particle radius on the conductance change are studied. This study gives a fundamental understanding and provides valuable suggestions to understand the translocation of biomolecular attached metal nanoparticles through nanopores. The results indicate a novel way for direct observation and study of nonlinear electrophoresis of single nanoparticles using nanopore technique as well.