Total Synthesis of Sedum Alkaloids via Catalyst Controlled aza-Cope Rearrangement and Hydroformylation with Formaldehyde

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• 作者：Hong Ren ; William D. Wulff
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：January 18, 2013
• 年：2013
• 卷：15
• 期：2
• 页码：242-245
• 全文大小：328K
• 年卷期：v.15,no.2(January 18, 2013)
• ISSN：1523-7052

文摘

The catalytic asymmetric aminoallylation of chiral aldehydes is developed as a new method for the catalyst controlled synthesis of syn- and anti-1,3-aminoalcohols. This methodology is highlighted in the synthesis of the sedum alkaloids (+)-sedridine and (+)-allosedridine both of which have their final carbon incorporated during closure of the piperidine ring via a hydroformylation with formaldehyde.