Epithelial Ovarian Cancer: Disease Etiology, Treatment, Detection, and Investigational Gene, Metabolite, and Protein Biomarkers

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• 作者：Taufika Islam Williams ; Kristina L. Toups ; Diana A. Saggese ; Kimberly R. Kalli ; William A. Cliby ; David C. Muddiman
• 刊名：Journal of Proteome Research
• 出版年：2007
• 出版时间：August 2007
• 年：2007
• 卷：6
• 期：8
• 页码：2936 - 2962
• 全文大小：1028K
• 年卷期：v.6,no.8(August 2007)
• ISSN：1535-3907

文摘

Cancer research in recent years has immensely benefited from the development of novel technologiesthat enable scientists to perform detailed investigations of genomes, transcriptomes, proteomes, andmetabolomes. This has invariably furthered knowledge of tumorigenesis and etiology of cancer. Theresulting information can, in the foreseeable future, effect a significant change in the pace of cancerresearch, thereby producing improvements in patient care. Ovarian cancer in particular has receivedthe interest of the scientific community, being the most frequent cause of death from gynecologicalcancers, characterized by few early symptoms, diagnosis at an advanced stage, as well as poorprognosis. Ovarian cancer is a malignancy in which normal ovarian cells begin to grow in anuncontrolled, abnormal manner and produce tumors in one or both ovaries. Epithelial cancers, themost common ovarian cancers (>80%), develop from cells lining the ovarian surface. Most ovariancancer research is primarily focused on the early detection and treatment of epithelial ovarian cancer,the more common ovarian malignancy. This review offers an introduction to ovarian cancer, withparticular emphasis on human epithelial ovarian cancer. Current methods of detection and therapyare discussed. A survey of promising new protein, gene, and metabolite biomarkers on the horizon isprovided. Future prospects for improved diagnosis are offered.