Self-Reporting Degradable Fluorescent Grafted Copolymer Micelles Derived from Biorenewable Resources

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• 作者：Amandine Noel ; Yannick P. Borguet ; Karen L. Wooley
• 刊名：ACS Macro Letters
• 出版年：2015
• 出版时间：June 16, 2015
• 年：2015
• 卷：4
• 期：6
• 页码：645-650
• 全文大小：307K
• ISSN：2161-1653

文摘

A series of hydrolytically degradable fluorescent poly(ferulic acid-co-tyrosine)-g-mPEG graft copolymers were synthesized and shown to undergo self-assembly in aqueous media to yield fluorescent micelles. The polymers and their micellar assemblies exhibited greater fluorescence emission intensity than did their small molecular building blocks, which provides a self-reporting character that has potential for monitoring the polymer integrity and also for performing in theranostics applications. The amphiphilic graft-copolymers were synthesized by Cu-assisted azide鈥揳lkyne 鈥渃lick鈥?addition of azido-functionalized mPEG polymers onto fluorescent degradable hydrophobic copolymers displaying randomly distributed alkyne side-chain groups along their biorenewably derived poly(ferulic acid-co-tyrosine) backbones. The morphologies and photophysical properties of the supramolecular assemblies generated in aqueous solutions were evaluated by DLS, TEM, AFM, and steady-state optical spectroscopies. The 15鈥?0 nm sized micelles behaved as broad-band emitters in the 350鈥?00 nm range, which highlights their potential as self-reporting nanomaterials for in vitro studies.