Cu-Catalyzed Stereoselective γ-Alkylation of Enones

详细信息    查看全文

• 作者：Xiaohong Chen ; Xiaoguang Liu ; Justin T. Mohr
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：May 25, 2016
• 年：2016
• 卷：138
• 期：20
• 页码：6364-6367
• 全文大小：412K
• 年卷期：0
• ISSN：1520-5126

文摘

A general regio- and stereoselective γ-C–C bond formation is achieved using α-halocarbonyl compounds and dienol ethers via Cu(II) catalysis. This method constitutes a novel approach to the challenging 1,6-dioxygenation motif. A range of γ-substituted enones, including many bearing all-carbon quaternary centers, are available through a simple protocol under mild reaction conditions with superb functional group compatibility. Excellent stereoinduction is observed providing controlled access to challenging stereochemical arrays.