Tracing Origins of Complex Pharmaceutical Preparations Using Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry

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• 作者：Xinglei Zhang ; Bin Jia ; Keke Huang ; Bin Hu ; Rong Chen ; Huanwen Chen
• 刊名：Analytical Chemistry
• 出版年：2010
• 出版时间：October 1, 2010
• 年：2010
• 卷：82
• 期：19
• 页码：8060-8070
• 全文大小：504K
• 年卷期：v.82,no.19(October 1, 2010)
• ISSN：1520-6882

文摘

A novel strategy to trace the origins of commercial pharmaceutical products has been developed based on the direct chemical profiling of the pharmaceutical products by surface desorption atmospheric pressure chemical ionization mass spectrometry (DAPCI-MS). Besides the unambiguous identification of active drug components, various compounds present in the matrixes are simultaneously detected without sample pretreatment, providing valuable information for drug quality control and origin differentiation. Four sources of commercial amoxicillin products made by different manufacturers have been successfully differentiated. This strategy has been extended to secerning six sources of Liuwei Dihuang Teapills, which are herbal medicine preparations with extremely complex matrixes. The photolysis status of chemical drug products and the inferior natural herd medicine products prepared with different processes (e.g., extra heating) were also screened using the method reported here. The limit of detection achieved in the MS/MS experiments was estimated to be 1 ng/g for amoxicillin inside the capsule product. Our experimental data demonstrate that DAPCI-MS is a useful tool for rapid pharmaceutical analysis, showing promising perspectives for tracking the entire pharmaceutical supply chain to prevent counterfeit intrusions.