Benzoic Acid Catalyzed Annulations of 伪-Amino Acids and Aromatic Aldehydes Containing an ortho-Michael Acceptor: Access to 2,5-Dihydro-1H-benzo[c]azepines and 10,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a]az
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- 作者：Mi Tang ; Lingfeng Tong ; Lei Ju ; Wanwan Zhai ; Yang Hu ; Xinhong Yu
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：November 6, 2015
- 年：2015
- 卷：17
- 期：21
- 页码：5180-5183
- 全文大小：379K
- ISSN：1523-7052
文摘
A novel one-pot efficient synthesis of 2,5-dihydro-1H-benzo[c]azepines and 10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a]azepines from 伪-amino acids and aromatic aldehydes containing an ortho-Michael acceptor is reported via decarboxylative annulations without metal catalysts in yields of 52鈥?1%. Under microwave irradiation, this protocol provides rapid access to polycyclic ring systems (only 5 min in most cases).