Direct C鈥揌 Trifluoromethylation of Glycals by Photoredox Catalysis
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- 作者：Bang Wang ; De-Cai Xiong ; Xin-Shan Ye
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：November 20, 2015
- 年：2015
- 卷：17
- 期：22
- 页码：5698-5701
- 全文大小：373K
- ISSN：1523-7052
文摘
A mild, efficient, and practical transformation for the direct C鈥揌 trifluoromethylation of glycals under visible light has been reported for the first time. This reaction employed fac-Ir3+(ppy)3 as the photocatalyst, Umemoto鈥檚 reagent as the CF3 source, and a household blue LED or sunlight as the light source. Glycals bearing both electron-withdrawing and -donating protective groups performed this reaction smoothly. This visible light-mediated trifluoromethylation reaction was highlighted by the trifluoromethylation of the biologically important Neu2en moiety.