Diterpenoid Alkaloids from the Lateral Root of Aconitum carmichaelii

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• 作者：Bingya Jiang ; Sheng Lin ; Chenggen Zhu ; Sujuan Wang ; Yanan Wang ; Minghua Chen ; Jianjun Zhang ; Jinfeng Hu ; Naihong Chen ; Yongchun Yang ; Jiangong Shi
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：June 22, 2012
• 年：2012
• 卷：75
• 期：6
• 页码：1145-1159
• 全文大小：413K
• 年卷期：v.75,no.6(June 22, 2012)
• ISSN：1520-6025

文摘

Twenty-six new diterpenoid alkaloids, 1鈥?b>26 (1鈥?b>4: hetisan-type C₂₀-diterpenoid alkaloids; 5鈥?b>26: aconitane C₁₉-diterpenoid alkaloids), and two known analogues, hypaconitine 27 and benzoylmesaconine 28, have been isolated from a water extract of the lateral root of Aconitum carmichaelii. Compounds 7 and 8 are rare examples of conformational isomers obtained from the same material. The conformation and conformational transformation of ring A in the C₁₉-diterpenoid alkaloids are discussed on the basis of NMR data analysis in combination with single-crystal X-ray crystallography of 6 and 27 by anomalous scattering of Cu K伪 radiation. In preliminary analgesic and toxicity assays, the isomer with ring A in the chair conformation (8 or 27) was found to be more active than that with ring A in the boat conformation (7 or 27a). In addition, 15, 16, and 19 showed neuroprotective activity.