Selective Modification of Halloysite Nanotubes with 1-Pyrenylboronic Acid: A Novel Fluorescence Probe with Highly Selective and Sensitive Response to Hyperoxide

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• 作者：Hailei Zhang ; Tianfei Ren ; Yunjing Ji ; Lingui Han ; Yonggang Wu ; Hongzan Song ; Libin Bai ; Xinwu Ba
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：October 28, 2015
• 年：2015
• 卷：7
• 期：42
• 页码：23805-23811
• 全文大小：476K
• ISSN：1944-8252

文摘

A novel fluorescence probe based on modified halloysite nanotubes (HNTs) by using 1-pyrenylboronic acid selectively grafted onto the inner surface of lumen was successfully achieved. The solid-state nuclear magnetic resonance (¹³C and ¹¹B), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) confirmed that the boronic acid group only binds to alumina at the tube lumen and does not bind the tube鈥檚 outer siloxane surface. The modified HNTs (HNTs-PY) inherit the spectroscopic properties relating to the pyrene units. Interestingly, the established Al鈥揙鈥揃 linkage gives the H₂O₂-sensitivity to pyrene grafted tubes. HNTs-PY exhibits a highly specific 鈥渢urn-off鈥?response for hyperoxide over other reactive oxygen species (ROS) and oxidative ions owing to their chemoselective boronate-to-phenol switch. The 鈥渢urn-off鈥?response can even be tracked when the additional amount of H₂O₂ was limited to 1 脳 10^鈥? mol. Thus, the selective modification method under mild conditions for the design of novel organic鈥搃norganic hybrid fluorescence probe may open up a broader application as well as for identification and diagnosis.