Modular-DNA Programmed Molecular Construction of 鈥淔ixed鈥?of 2D and 3D-Au Nanoparticle Arrays

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• 作者：Zhijie Ma ; Wen Chen ; Matthew C. Johnson ; Ingeborg Schmidt-Krey ; Loren Williams ; Gary B. Schuster
• 刊名：Chemistry of Materials
• 出版年：2014
• 出版时间：October 14, 2014
• 年：2014
• 卷：26
• 期：19
• 页码：5499-5505
• 全文大小：461K
• ISSN：1520-5002

文摘

Specifically designed dimeric, planar trimeric, tetrameric, pentameric, and 3D hexameric assemblies of Au nanoparticles were constructed from self-assembling DNA modules that contain disulfide groups, for attachment to the nanoparticles, and covalently linked 2,5-bis(2-thienyl)pyrrole (SNS) monomers. Treatment of these arrays with horseradish peroxidase and H₂O₂ (HRP/H₂O₂) results in bond formation between the SNS monomers that cross-links or ligates the DNA modules making the assemblies permanent (鈥渇ixed鈥?.