Cyclodextrin-Responsive Micelles Based on Poly(ethylene glycol)鈥揚olypeptide Hybrid Copolymers as Drug Carriers
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- 作者：Kang Wang ; Yun Liu ; Cao Li ; Si-Xue Cheng ; Ren-Xi Zhuo ; Xian-Zheng Zhang
- 刊名：ACS Macro Letters
- 出版年：2013
- 出版时间：March 19, 2013
- 年：2013
- 卷：2
- 期：3
- 页码：201-205
- 全文大小：296K
- 年卷期：v.2,no.3(March 19, 2013)
- ISSN：2161-1653
文摘
Novel drug carriers based on poly(ethylene glycol) (PEG)鈥損olypeptide copolymers, four-armed poly(蔚-adamantane-l-lysine)2-block-poly(ethylene glycol)-block-poly(蔚-adamantane-l-lysine)2 (PLys(Ad)2-b-PEG-b-PLys(Ad)2), have been prepared. The copolymers were synthesized via the ring-opening polymerization of amino acid N-carboxyanhydrides. The copolymers could spontaneously form core鈥搒hell micelles in aqueous solutions. It has been found that these micelles undergo triggered disassembly in response to an additional 尾-cyclodextrin (尾-CD). The in vitro drug release in response to 尾-CD has been studied, and the result shows that the release of the entrapped drug doxorubicin (DOX) from the micelles could be accelerated by the addition of 尾-CD. Their cytotoxicity and cell internalization behavior were also investigated in detail. These micelles are expected to have great potential in controlled drug release applications.