CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementation
详细信息 查看全文
- 作者：A. Arabi ; N . Khoueiry-Zgheib ; Z. Awada ; R. Mahfouz…
- 关键词：25(OH) vitamin D ; CYP2R1 ; Genetic polymorphisms ; Metabolic pathway ; Vitamin D supplementation
- 刊名：Osteoporosis International
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：28
- 期：1
- 页码：279-290
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Orthopedics; Endocrinology; Rheumatology;
- 出版者：Springer London
- ISSN：1433-2965
- 卷排序：28
文摘
SummaryWe studied the association between CYP2R1 genetic polymorphisms and circulating 25-hydroxyvitamin D [25(OH)D] before and after supplementation with vitamin D3 in 218 elderly. We found differences between 3 and 8 ng/ml in circulating levels at baseline in women but not in the response after 1 year of supplementation.