CD40 expression and its prognostic significance in human gastric carcinoma

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• 作者：Jing Guo (1)
  Jia-Jia Xiao (2)
  Xiaoli Zhang (3)
  Kai-Xi Fan (1)
  
  1. The Affiliated Hospital of Shandong Academy of Medical Sciences ; University of Jinan ; No. 38 Wu Ying-Shan Road ; Tianqiao District ; Jinan ; 250031 ; Shandong Province ; China
  2. Shanghai First People鈥檚 Hospital ; School of Medicine ; Shanghai Jiao Tong University ; No. 100 Haining Road ; Hongkou District ; Shanghai ; 200080 ; China
  3. Department of Oncology ; Renmin Hospital of Wuhan University ; No. 238 Jiefang Road ; Wuchang District ; Wuhan ; 430060 ; Hubei Province ; China
  
• 关键词：CD40 ; Gastric cancer ; TNM stage ; Metastasis
• 刊名：Medical Oncology
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：32
• 期：3
• 全文大小：637 KB
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• 刊物主题：Oncology; Hematology; Pathology; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-131X

文摘

This study aimed to detect the relationship between CD40 (protein and mRNA) expression and human gastric cancer and to determine the prognostic significance of CD40 in gastric cancer patients. We collected 128 cases of gastric cancer specimens, and the expression of CD40 (protein and mRNA) was measured by immunohistochemistry and in situ hybridization. Our study indicated that CD40 is constitutively expressed in human gastric carcinoma tissues. Positive expression of CD40 (protein and mRNA) in gastric cancer tissues was closely related to the tumor TNM stage and the presence of distant metastasis, with CD40 mRNA also being correlated with the presence of lymphatic metastasis. Furthermore, the expression of CD40 (protein and mRNA) is closely related to the prognosis of gastric cancer patients. The expression of CD40 protein and mRNA is positively correlated with the presence of distant (for both protein and mRNA) and lymphatic (for mRNA only) metastasis, and an increased tumor TNM stage in gastric carcinoma. Patients who express low levels of CD40 may have a better prognosis than those who have higher levels of CD40.