Intramedullary spinal cord metastasis of cholangiocarcinoma: a case report

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• 作者：Laurence Faugeras (1)
  Gaetan Cantineau (2)
  Jean-Francois Daisne (3)
  Thierry Gustin (4)
  Lionel D鈥檋ondt (1)
  
  1. Department of Medical Oncology ; Centre Hospitalier Universitaire Dinant-Godinne ; 1 Rue Dr G. Therasse ; 5530 ; Yvoir ; Belgium
  2. Department of Radiology ; Centre Hospitalier Universitaire DinantMont-Godinne ; Yvoir ; Belgium
  3. Department of Radiotherapy ; Clinique et maternit茅 sainte-Elisabeth ; Namur ; Belgium
  4. Department of Neurosurgery ; Centre Hospitalier Universitaire Dinant-Godinne ; Yvoir ; Belgium
  
• 关键词：Cholangiocarcinoma ; Intramedullary spinal cord metastasis ; Brain metastasis
• 刊名：BMC Research Notes
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：8
• 期：1
• 全文大小：3,447 KB
• 参考文献：1. Tompkins, RK, Thomas, D, Wile, A, Longmire, WP (1981) Prognostic factors in bile duct carcinoma: analysis of 96 cases. Ann Surg 194: pp. 447-57 CrossRef
  2. William, BM, Grem, JL (2011) Brain metastasis and leptomeningeal carcinomatosis in a patient with cholangiocarcinoma. Gastrointest Cancer Res 4: pp. 144-5
  3. Huffman, JL, Yeatman, TJ, Smith, JB (1997) Leptomeningeal carcinomatosis: a sequela of cholangiocarcinoma. Am Surg 63: pp. 310-3
  4. Okamura, Y, Harada, A, Maeda, A, Fujioka, A, Horiba, T, Ishigure, K (2008) Carcinomatous meningitis secondary to cholangiocarcinoma without other systemic metastasis. J Hepatobiliary Pancreat Surg 115: pp. 237-9 CrossRef
  5. Kalayci, M, Ca臒avi, F, G眉l, S, Yenid眉nya, S, A莽ikg枚z, B (2004) Intramedullary spinal cord metastases: diagnosis and treatment 鈥?an illustrated review. Acta Neurochir 146: pp. 1347-54 CrossRef
  6. Sung, WS, Sung, MJ, Chan, JH, Manion, B, Song, J, Dubey, A (2013) Intramedullary spinal cord metastases: a 20-year institutional experience with a comprehensive literature review. World Neurosur 79: pp. 576-84 CrossRef
  7. Hashii, H, Mizumoto, M, Kanemoto, A, Harada, H, Asakura, H, Hashimoto, T (2011) Radiotherapy for patients with symptomatic intramedullary spinal cord metstasis. J Radiat Res 52: pp. 641-5 CrossRef
  8. Rykken, JB, Diehn, FE, Hunt, CH, Schwartz, KM, Eckel, LJ, Wood, CP (2013) Intramedullary spinal cord metastases: MRI and relevant clinical features from a 13-year institutional case series. Am J Neuroradiol 34: pp. 2043-9 CrossRef
  9. Flanagan, EP, Hunt, CH, Lowe, V, Mandrekar, J, Pittock, SJ, O鈥橬eill, BP (2013) [(18)F]-fluorodeoxyglucose-positron emission tomography in patients with active myelopathy. Mayo Clin Proc 88: pp. 1204-12 CrossRef
  10. Hrabalek, L (2010) Intramedullary spinal cord metastases: rewiev of literature. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 154: pp. 117-22 CrossRef
  11. Gilardi, L, Vassallo, S, Colandrea, M, Travaini, LL, Paganelli, G (2013) Intramedullary spinal cord metastases from breast cancer: detection with (18)F-FDG PET/CT. Ecancer Med Sci 1: pp. 7
  12. Poggi, MM, Patronas, N, Buttman, JA, Hewitt, SM, Fuller, B (2001) Intramedullary spinal cord metastasis from renal cell carcinoma: detection by positron emission tomography. Clin Nucl Med 26: pp. 837-9 CrossRef
  13. Nguyen, NC, Sayed, MM, Taalab, K, Osman, MM (2008) Spinal cord metastases from lung cancer: detection with F-18 FDG PET/CT. Clin Nucl Med 33: pp. 356-8 CrossRef
  14. Ram铆rez-Merino, N, Aix, SP, Cort茅s-Funes, H (2013) Chemotherapy for cholangiocarcinoma: an update. World J Gastrointest Oncol 5: pp. 171-6 CrossRef
  15. He, XR, Wu, XP (2008) Difference in biological characteristics and sensitivity to chemotherapy and radiotherapy between intrahepatic and extrahepatic cholangiocarcinoma cells in vitro. Chin Med Sci J 23: pp. 54-9 CrossRef
  16. Weinbren, K, Mutum, SS (1983) Pathological aspects of cholangiocarcinoma. J Pathol 139: pp. 217-38 CrossRef
  17. Valle, J, Wasan, H, Palmer, DH, Cunningham, D, Anthoney, A, Maraveyas, A (2010) ABC-02 trial investigators: cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med 362: pp. 1273-81 CrossRef
  
• 刊物主题：Biomedicine general; Medicine/Public Health, general; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1756-0500

文摘

Background Cholangiocarcinomas are rare tumors, and metastasis to the intramedullary spinal cord is also rare. To the best of our knowledge, this is the first case of simultaneous cholangiocarcinoma and intramedullary spinal cord metastasis to be described in the medical literature. Case presentation A 62-year-old Caucasian male with a cholangiocarcinoma presented pain around his left shoulder without any other symptoms. The results by magnetic resonance imaging and F18 fluorodeoxyglucose positron emission tomography/computer tomography revealed an intramedullary metastasis at the C4 level, with spinal cord compression, and numerous secondary parenchymal brain metastases. Conclusion This patient was treated successfully with a combination of radiotherapy, corticosteroids, and chemotherapy. He experienced complete relief of the symptoms and showed improvements upon subsequent radiological evaluations.