Chimeric Peptides as Implant Functionalization Agents for Titanium Alloy Implants with Antimicrobial Properties

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• 作者：Deniz T. Yucesoy (1)
  Marketa Hnilova (1)
  Kyle Boone (2)
  Paul M. Arnold (3)
  Malcolm L. Snead (4)
  Candan Tamerler (5)
  
  1. Department of Materials Science and Engineering ; GEMSEC ; Genetically Engineered Materials Science and Engineering Center ; University of Washington ; Seattle ; WA ; 98195 ; USA
  2. Bioengineering Program and Bioengineering Research Center ; University of Kansas ; Lawrence ; KS ; 66045 ; USA
  3. Department of Neurosurgery ; School of Medicine ; Spinal Cord Injury Center ; University of Kansas ; Kansas City ; KS ; 66160 ; USA
  4. Ostrow School of Dentistry of USC ; Center for Craniofacial Molecular Biology ; University of Southern California ; Los Angeles ; CA ; 90032 ; USA
  5. Department of Mechanical Engineering & Bioengineering Research Center ; University of Kansas ; Lawrence ; KS ; 66045 ; USA
  
• 刊名：JOM Journal of the Minerals, Metals and Materials Society
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：67
• 期：4
• 页码：754-766
• 全文大小：1,725 KB
• 参考文献：1. Bauer, S, Schmuki, P, Mark, K, Park, J (2013) Prog. Mater. Sci. 58: pp. 261 CrossRef
  2. Puleo, D, Nanci, A (1999) Biomaterials 20: pp. 2311 CrossRef
  3. Geetha, M, Singh, A, Asokamani, R, Gogia, A (2009) Prog. Mater. Sci. 54: pp. 397 CrossRef
  4. Gu茅hennec, L, Soueidan, A, Layrolle, P, Amouriq, Y (2007) Dent. Mater. 23: pp. 844 CrossRef
  5. Pennekamp, PH, Gessmann, J, Diedrich, O, Burian, B, Wimmer, MA, Frauchiger, VM, Kraft, CN (2006) J. Orthop. Res. 24: pp. 531 CrossRef
  6. Costerton, J, Stewart, PS, Greenberg, E (1999) Science 284: pp. 1318 CrossRef
  7. Weinstein, RA, Darouiche, RO (2001) Clin. Infect. Dis. 33: pp. 1567 CrossRef
  8. U莽kay, I, Hoffmeyer, P, Lew, D, Pittet, D (2013) J. Hosp. Infect. 84: pp. 5 CrossRef
  9. Antoci, V, Adams, CS, Parvizi, J, Davidson, HM, Composto, RJ, Freeman, TA, Wickstrom, E, Ducheyne, P, Jungkind, D, Shapiro, IM (2008) Biomaterials 29: pp. 4684 CrossRef
  10. Kazemzadeh-Narbat, M, Kindrachuk, J, Duan, K, Jenssen, H, Hancock, RE, Wang, R (2010) Biomaterials 31: pp. 9519 CrossRef
  11. Rathbone, CR, Cross, JD, Brown, KV, Murray, CK, Wenke, JC (2011) J. Orthop. Res. 29: pp. 1070 CrossRef
  12. Hetrick, EM, Schoenfisch, MH (2006) Chem. Soc. Rev. 35: pp. 780 CrossRef
  13. Campoccia, D, Montanaro, L, Speziale, P, Arciola, CR (2010) Biomaterials 31: pp. 6363 CrossRef
  14. Harbers, GM, Emoto, K, Greef, C, Metzger, SW, Woodward, HN, Mascali, JJ, Grainger, DW, Lochhead, MJ (2007) Chem. Mater. 19: pp. 4405 CrossRef
  15. Shimotoyodome, A, Koudate, T, Kobayashi, H, Nakamura, J, Tokimitsu, I, Hase, T, Inoue, T, Matsukubo, T, Takaesu, Y (2007) Antimicrob. Agents Chemother. 51: pp. 3634 CrossRef
  16. An, Y, Stuart, G, McDowell, S, McDaniel, S, Kang, Q, Friedman, R (1996) J. Orthop. Res. 14: pp. 846 CrossRef
  17. Jose, B, Antoci, V, Zeiger, AR, Wickstrom, E, Hickok, NJ (2005) Chem. Biol. 12: pp. 1041 CrossRef
  18. Price, J, Tencer, A, Arm, D, Bohach, G (1996) J. Biomed. Mater. Res. 30: pp. 281 CrossRef
  19. Russell, A, Tattawasart, U, Maillard, J-Y, Furr, J (1998) Antimicrob. Agents Chemother. 42: pp. 2151
  20. Wininger, DA, Fass, RJ (1996) Antimicrob. Agents Chemother. 40: pp. 2675
  21. Harris, L, Mead, L, M眉ller-Oberl盲nder, E, Richards, R (2006) J. Biomed. Mater. Res. A 78: pp. 50 CrossRef
  22. Banerjee, I, Pangule, RC, Kane, RS (2011) Adv. Mater. 23: pp. 690 CrossRef
  23. Zhao, L, Chu, PK, Zhang, Y, Wu, Z (2009) J. Biomed. Mater. Res. B Appl. Biomater. 91: pp. 470 CrossRef
  24. Gottenbos, B, Mei, HC, Klatter, F, Nieuwenhuis, P, Busscher, HJ (2002) Biomaterials 23: pp. 1417 CrossRef
  25. Mrksich, M, Whitesides, GM (1996) Annu. Rev. Biophys. 25: pp. 55 CrossRef
  26. Mohor膷i膷, M, Jerman, I, Zorko, M, Butinar, L, Orel, B, Jerala, R, Friedrich, J (2010) J. Mater. Sci. Mater. Med. 21: pp. 2775 CrossRef
  27. Love, JC, Estroff, LA, Kriebel, JK, Nuzzo, RG, Whitesides, GM (2005) Chem. Rev. 105: pp. 1103 CrossRef
  28. Harris, LG, Richards, RG (2006) Injury 37: pp. S3 CrossRef
  29. Brogden, KA (2005) Nat. Rev. Microbiol. 3: pp. 238 CrossRef
  30. Giuliani, A, Pirri, G, Nicoletto, SF (2007) Cent. Eur. J. Biol. 2: pp. 1 CrossRef
  31. Zasloff, M (2002) Nature 415: pp. 389 CrossRef
  32. Reddy, K, Yedery, R, Aranha, C (2004) Int. J. Antimicrob. Agents 24: pp. 536 CrossRef
  33. Pasupuleti, M, Schmidtchen, A, Malmsten, M (2012) Crit. Rev. Biotechnol. 32: pp. 143 CrossRef
  34. Jenssen, H, Hamill, P, Hancock, RE (2006) Clin. Microbiol. Rev. 19: pp. 491 CrossRef
  35. Ingham, AB, Moore, RJ (2007) Biotechnol. Appl. Biochem. 47: pp. 1 CrossRef
  36. Hilpert, K, Elliott, MR, Volkmer-Engert, R, Henklein, P, Donini, O, Zhou, Q, Winkler, DF, Hancock, RE (2006) Chem. Biol. 13: pp. 1101 CrossRef
  37. Fjell, CD, Jenssen, H, Hilpert, K, Cheung, WA, Pante, N, Hancock, RE, Cherkasov, A (2009) J. Med. Chem. 52: pp. 2006 CrossRef
  38. Jiang, Z, Vasil, AI, Hale, JD, Hancock, RE, Vasil, ML, Hodges, RS (2008) J. Pept. Sci. 90: pp. 369 CrossRef
  39. Sarikaya, M, Tamerler, C, Jen, AK-Y, Schulten, K, Baneyx, F (2003) Nat. Mater. 2: pp. 577 CrossRef
  40. Campoccia, D, Montanaro, L, Arciola, CR (2013) Biomaterials 34: pp. 8533 CrossRef
  41. Kwakman, PH, Velde, AA, Vandenbroucke-Grauls, CM, Deventer, SJ, Zaat, SA (2006) Antimicrob. Agents Chemother. 50: pp. 3977 CrossRef
  42. Etienne, O, Picart, C, Taddei, C, Haikel, Y, Dimarcq, J, Schaaf, P, Voegel, J, Ogier, J, Egles, C (2004) Antimicrob. Agents Chemother. 48: pp. 3662 CrossRef
  43. Appendini, P, Hotchkiss, J (2001) J. Appl. Polym. Sci. 81: pp. 609 CrossRef
  44. Yan, Z, Snead, ML, Tamerler, C (2015) Nanomedicine 11: pp. 431 CrossRef
  45. Socransky, SS, Haffajee, AD (2002) Periodontology 2000 28: pp. 12 CrossRef
  46. Campoccia, D, Montanaro, L, Arciola, CR (2006) Biomaterials 27: pp. 2331 CrossRef
  47. Costa, F, Carvalho, IF, Montelaro, RC, Gomes, P, Martins, MCL (2011) Acta Biomater. 7: pp. 1431 CrossRef
  48. Meyers, SR, Khoo, X, Huang, X, Walsh, EB, Grinstaff, MW, Kenan, DJ (2009) Biomaterials 30: pp. 277 CrossRef
  49. Yoshinari, M, Kato, T, Matsuzaka, K, Hayakawa, T, Shiba, K (2010) Biofouling 26: pp. 103 CrossRef
  50. Yazici, H, Fong, H, Wilson, B, Oren, E, Amos, F, Zhang, H, Evans, J, Snead, M, Sarikaya, M, Tamerler, C (2013) Acta Biomater. 9: pp. 5341 CrossRef
  51. Oren, EE, Tamerler, C, Sahin, D, Hnilova, M, Seker, UOS, Sarikaya, M, Samudrala, R (2007) Bioinformatics 23: pp. 2816 CrossRef
  52. Lu, Z, Murray, KS, Cleave, V, LaVallie, ER, Stahl, ML, McCoy, JM (1995) Nat. Biotechnol. 13: pp. 366 CrossRef
  53. Tamerler, C, Khatayevich, D, Gungormus, M, Kacar, T, Oren, EE, Hnilova, M, Sarikaya, M (2010) J. Pept. Sci. 94: pp. 78 CrossRef
  54. Tamerler, C, Sarikaya, M (2007) Acta Biomater. 3: pp. 289 CrossRef
  55. Seker, UOS, Wilson, B, Dincer, S, Kim, IW, Oren, EE, Evans, JS, Tamerler, C, Sarikaya, M (2007) Langmuir 23: pp. 7895 CrossRef
  56. Fjell, CD, Jenssen, H, Cheung, WA, Hancock, RE, Cherkasov, A (2011) Chem. Biol. Drug Des. 77: pp. 48 CrossRef
  57. Chaudhury, S, Lyskov, S, Gray, JJ (2010) Bioinformatics 26: pp. 689 CrossRef
  58. Simons, KT, Kooperberg, C, Huang, E, Baker, D (1997) J. Mol. Biol. 268: pp. 209 CrossRef
  59. Bradley, P, Misura, KM, Baker, D (2005) Science 309: pp. 1868 CrossRef
  60. Kabsch, W, Sander, C (1983) Biopolymers 22: pp. 2577 CrossRef
  61. Grzymala-Busse, JW, Rzasa, W (2010) Fund. Inform. 100: pp. 99
  62. Shepherd, NE, Hoang, HN, Abbenante, G, Fairlie, DP (2009) J. Am. Chem. Soc. 131: pp. 15877 CrossRef
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Materials Science
  Metallic Materials
  Nanotechnology
  Crystallography
  
• 出版者：Springer Boston
• ISSN：1543-1851

文摘

Implant-associated infections can have severe effects on the longevity of implant devices and they also represent a major cause of implant failures. Treating these infections associated with implants by antibiotics is not always an effective strategy due to poor penetration rates of antibiotics into biofilms. Additionally, emerging antibiotic resistance poses serious concerns. There is an urge to develop effective antibacterial surfaces that prevent bacterial adhesion and proliferation. A novel class of bacterial therapeutic agents, known as antimicrobial peptides (AMPs), are receiving increasing attention as an unconventional option to treat septic infection, partly due to their capacity to stimulate innate immune responses and for the difficulty of microorganisms to develop resistance towards them. While host and bacterial cells compete in determining the ultimate fate of the implant, functionalization of implant surfaces with AMPs can shift the balance and prevent implant infections. In the present study, we developed a novel chimeric peptide to functionalize the implant material surface. The chimeric peptide simultaneously presents two functionalities, with one domain binding to a titanium alloy implant surface through a titanium-binding domain while the other domain displays an antimicrobial property. This approach gains strength through control over the bio-material interfaces, a property built upon molecular recognition and self-assembly through a titanium alloy binding domain in the chimeric peptide. The efficiency of chimeric peptide both in-solution and absorbed onto titanium alloy surface was evaluated in vitro against three common human host infectious bacteria, Streptococcus mutans, Staphylococcus epidermidis, and Escherichia coli. In biological interactions such as occur on implants, it is the surface and the interface that dictate the ultimate outcome. Controlling the implant surface by creating an interface composed chimeric peptides may therefore open up new possibilities to modify the implant site and tailor it to a desirable bioactivity.