Three-component synthesis of pyrano[2,3-d]pyrimidinone derivatives catalyzed by Ni²⁺ supported on hydroxyapatite-core–shell-γ-Fe₂O₃ nanoparticles in aqueous medium

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• 作者：Sobhan Rezayati ; Zahra Abbasi ; Eshagh Rezaee Nezhad…
• 关键词：Nanoparticles ; Lewis acid catalyst ; Supported Ni2+ ; Multicomponent reaction ; Pyrano[2 ; 3 ; d]pyrimidinone ; Knoevenagel reaction
• 刊名：Research on Chemical Intermediates
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：42
• 期：10
• 页码：7597-7609
• 全文大小：816 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1568-5675
• 卷排序：42

文摘

Pyrano[2,3-d]pyrimidine derivatives were synthesized via one-pot, three-component condensation reaction of aromatic aldehydes, malononitrile, and barbituric acid in aqueous ethanol catalyzed by Ni2+ supported on hydroxyapatite-core–shell-γ-Fe₂O₃ nanoparticles (γ-Fe₂O₃@HAp-Ni2+ NPs) as Lewis acid. The nontoxic nature and easy handling of the catalyst, environmentally friendly and facile work-up procedure, short reaction time, low catalyst loading, and high effectiveness to give products in good to excellent yield are advantages of this approach. Also, γ-Fe₂O₃@HAp-Ni2+ NPs can be easily recovered and reused for at least six runs.