Zinc Chloride and Lead Acetate-Induced Passive Avoidance Memory Retention Deficits Reversed by Nicotine and Bucladesine in Mice

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• 作者：Kaveh Tabrizian ; Abdolmajid Yazdani ; Behnam Baheri…
• 关键词：Zinc chloride ; Lead acetate ; Nicotine ; Bucladesine ; Avoidance memory
• 刊名：Biological Trace Element Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：169
• 期：1
• 页码：106-113
• 全文大小：1,371 KB
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• 作者单位：Kaveh Tabrizian (1) (2)
  Abdolmajid Yazdani (1)
  Behnam Baheri (1)
  Borna Payandemehr (3)
  Mehdi Sanati (3)
  Mahmoud Hashemzaei (1)
  Abdolhossein Miri (2) (4)
  Majid Zandkarimi (5)
  Maryam Belaran (6)
  Sahar Fanoudi (7)
  Mohammad Sharifzadeh (3)
  
  1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
  2. Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran
  3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran
  4. Department of Pharmacognosy, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
  5. Department of Pharmaceutics, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
  6. Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  
• 刊物主题：Biochemistry, general; Biotechnology; Nutrition; Oncology;
• 出版者：Springer US
• ISSN：1559-0720

文摘

It is very important to investigate the neurotoxic effects of metals on learning and memory processes. In this study, we tried to investigate the effects and time course properties of oral administration of zinc chloride (25, 50, and 75 mg/kg, for 2 weeks), lead acetate (250, 750, 1,500, and 2,500 ppm for 4, 6 and 8 weeks), and their possible mechanisms on a model of memory function. For this matter, we examined the intra-peritoneal injections of nicotine (0.25, 0.5, 1, and 1.5 mg/kg) and bucladesine (50, 100, 300, and 600 nM/mouse) for 4 days alone and in combination with mentioned metals in the step-through passive avoidance task. Control animals received saline, drinking water, saline, and DMSO (dimethyl sulfoxide)/deionized water (1:9), respectively. At the end of each part of studies, animals were trained for 1 day in step-through task. The avoidance memory retention alterations were evaluated 24 and 48 h later in singular and combinational studies. Zinc chloride (75 mg/kg) oral gavage for 2 weeks decreased latency times compared to control animals. Also, lead acetate (750 ppm oral administrations for 8 weeks) caused significant lead blood levels and induced avoidance memory retention impairments. Four-days intra-peritoneal injection of nicotine (1 mg/kg) increased latency time compared to control animals. Finally, findings of this research showed that treatment with intra-peritoneal injections of nicotine (1 mg/kg) and/or bucladesine (600 nM/mouse) reversed zinc chloride- and lead acetate-induced avoidance memory retention impairments. Taken together, these results showed the probable role of cholinergic system and protein kinase A pathways in zinc chloride- and lead acetate-induced avoidance memory alterations.