Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians
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- 作者：Young Ho Lee (1)
Gwan Gyu Song (1) - 关键词：Asthma ; ADAM33 ; Polymorphism ; Meta ; analysis
- 刊名：Inflammation Research
- 出版年：2012
- 出版时间：December 2012
- 年：2012
- 卷：61
- 期：12
- 页码：1355-1362
- 全文大小：340KB
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Gwan Gyu Song (1)
1. Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea - ISSN：1420-908X
文摘
Objective The aim of this study was to determine whether the ADAM33 (a disintegrin and metalloproteinase domain 33) T1 (rs2280091), T2 (rs2280090), and ST+7 (rs574174) polymorphisms confer susceptibility to asthma. Methods A meta-analysis stratified by ethnicity and age was conducted on associations between the ADAM33 T1, T2, and ST+7 polymorphisms and asthma. Results Eleven studies, which included 4,124 patients and 7,094 controls, were available for the meta-analysis. Meta-analysis revealed an association between asthma and the ADAM33 T1 GG genotype [odds ratio (OR)?=?2.257, 95?% confidence interval (CI)?=?1.577-.228, p?=?8.42?×?10?]. Stratification by ethnicity indicated an association between this genotype and asthma in Asians (OR?=?2.683, 95?% CI?=?1.799-.001, p?=?1.31?×?10?), and stratification by age indicated an association between it and asthma in adults (OR?=?1.895, 95?% CI?=?1.005-.573, p?=?0.048). However, no association was found between asthma and the ADAM33 T2 and ST+7 polymorphisms. Conclusions This meta-analysis demonstrates that the ADAM33 T1 polymorphism confers susceptibility to asthma in Asians, but no association was found between the ADAM33 T2 and ST+7 polymorphisms and asthma susceptibility.