Identification of new synthetic cannabinoid analogue APINAC (adamantan-1-yl 1-pentyl-1H-indazole-3-carboxylate) with other synthetic cannabinoid MDMB(N)-Bz-F in illegal products

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• 作者：Ji Hyun Lee ; Han Na Park ; Tan-Soon Leem ; Joo-hyoung Jeon…
• 关键词：Methyl 2 ; [1 ; (4 ; fluorobenzyl) ; 1H ; indazole ; 3 ; carboxamido] ; 3 ; 3 ; dimethylbutanoate ; 1 ; (4 ; Fluorobenzyl) ; N ; (1 ; methoxycarbonyl ; 2 ; 2 ; dimethylpropyl) ; 1H ; indazole ; 3 ; carboxamide [MDMB(N) ; Bz ; F] ; Adamantan ; 1 ; yl 1 ; pentyl ; 1H ; indazole ; 3 ; carboxylate (APINAC) ; Synthetic cannabinoids ; Illegal product ; APINACA analogues
• 刊名：Forensic Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：35
• 期：1
• 页码：45-55
• 全文大小：
• 刊物主题：Forensic Medicine; Pharmacology/Toxicology; Medicinal Chemistry; Medicine/Public Health, general; Medical Law;
• 出版者：Springer Japan
• ISSN：1860-8973
• 卷排序：35

文摘

Two synthetic cannabinoid analogues were detected using high-performance liquid chromatography (HPLC)–diode array detector, and gas chromatography–time-of-flight-mass spectrometry during the inspection of illegal products in an airmail package. The analogues were separated by semi-preparative HPLC, and their structures were determined by performing liquid chromatography–high-resolution-mass spectrometry, infrared analysis, and nuclear magnetic resonance spectroscopy. Compound 1 was MDMB(N)-Bz-F, which has been reported previously. Compound 2 was elucidated as adamantan-1-yl 1-pentyl-1H-indazole-3-carboxylate (APINAC), in which the amide group of APINACA was replaced with an ester group. Because there has been no chemical or pharmacological data about this compound until now, this is the first report of its detection in illegal products.