Survival variability of controls and definition of imaging endpoints for longitudinal follow-up of pancreatic ductal adenocarcinoma in rats
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- 作者：Cherif Akladios ; Mihaela Ignat…
- 关键词：Ductal adenocarcinoma ; Humane endpoints ; MicroCT scan ; Pancreas ; Rat ; 3Rs
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：143
- 期：1
- 页码：29-34
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-1335
- 卷排序：143
文摘
BackgroundThe 3Rs guideline is the gold standard for ethics in animal experimentation. Two of those rules, namely refinement and reduction, require further improvement. The objective of this study was to define pathways to better compliance with these prerequisites. Two methods which move us in this direction are: (1) using small animal imaging techniques for pancreatic ductal adenocarcinoma (PDAC) follow-up and (2) reduction of the number of control animals included in a study of PDAC progression under treatment.