Prospects for the use of sulfated polysaccharides from brown seaweeds as vaccine adjuvants
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- 作者：T. A. Kuznetsova ; T. S. Zaporozhets ; E. V. Persianova…
- 关键词：seaweeds ; sulfated polysaccharides ; fucoidans ; vaccines ; adjuvants ; immunostimulators ; TLR agonists
- 刊名：Russian Journal of Marine Biology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：42
- 期：6
- 页码：443-450
- 全文大小：
- 刊物主题：Freshwater & Marine Ecology;
- 出版者：Pleiades Publishing
- ISSN：1608-3377
- 卷排序：42
文摘
The data from the Russian and foreign literature on the effects of brown seaweed-derived sulfated polysaccharides (fucoidans) used as potential vaccine adjuvants to enhance the anti-infection and anti-tumor immune response are discussed in the present review. Due to their low toxicity, high biocompatibility, safety, and good tolerability by macroorganisms, as well as their mechanisms of immunomodulatory activity, fucoidans can be considered as promising adjuvants to administer in the composition of prophylactic and therapeutic vaccines. Fucoidans are agonists to receptors of innate immunity and are potent inducers of the cellular and humoral immune response, which is an important factor to be taken into account in the development of vaccines against various pathogens, including viruses, as well as anti-tumor vaccines. The results of numerous studies in which sulfated polysaccharides were tested as components of experimental vaccines, as presented in this review, show that these substances can be used as safe and effective adjuvants.