Effect of subchronic corticosterone administration on α₂-adrenoceptor functionality in rat brain: an in vivo and in vitro study

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• 作者：Igor Horrillo ; Jorge E. Ortega ; Rebeca Diez-Alarcia ; Leyre Urigüen…
• 关键词：Adrenoceptor ; Corticosterone ; HPA ; Mood disorders ; Depression
• 刊名：Psychopharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：233
• 期：23-24
• 页码：3861-3867
• 全文大小：464 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072
• 卷排序：233

文摘

RationaleNoradrenergic system plays a critical role in the hypothalamic-pituitary-adrenal (HPA) axis regulation and the stress response. A dysregulated HPA axis may be indicative of an increased biological vulnerability for depression. In addition, a variety of studies have focused on specific alterations of α₂-adrenoceptors as a mechanism involved in the pathogenesis of mood disorders and antidepressant response.