Association of apoptosis inhibitor of macrophage (AIM) expression with urinary protein and kidney dysfunction
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- 作者：Megumi Oshima ; Yasunori Iwata ; Kengo Furuichi…
- 关键词：Apoptosis inhibitor of macrophage (AIM) ; Kidney disease ; IgM
- 刊名：Clinical and Experimental Nephrology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：21
- 期：1
- 页码：35-42
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Nephrology; Urology;
- 出版者：Springer Japan
- ISSN：1437-7799
- 卷排序：21
文摘
BackgroundApoptosis inhibitor of macrophage (AIM) expressed on macrophages prolongs inflammation by protecting macrophages from apoptosis. Most circulating AIM co-exists with immunoglobulin M (IgM). AIM’s pathophysiological role in relation to IgM remains unclear. Here we evaluated the glomerular expression/deposition of AIM and IgM in the kidney using immunohistochemistry and its associations with clinical manifestations in 43 patients with biopsy-confirmed kidney diseases.