An improved method for preparing glutaraldehyde cross-linked chitosan鈥損oly(vinyl alcohol) microparticles
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- 作者：Elisa Campos (1) (2)
Patr铆cia Coimbra (1)
M. H. Gil (1) - 关键词：Microparticle ; Chitosan ; Poly(vinyl alcohol) ; Glutaraldehyde ; Water ; in ; oil emulsion ; Cytotoxicity
- 刊名：Polymer Bulletin
- 出版年：2013
- 出版时间：February 2013
- 年：2013
- 卷：70
- 期：2
- 页码：549-561
- 全文大小：714KB
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Patr铆cia Coimbra (1)
M. H. Gil (1)
1. Chemical Process Engineering and Forest Products Research Centre (CIEPQPF), Department of Chemical Engineering, Faculty of Sciences and Technology, University of Coimbra, Rua S铆lvio Lima, 3030-790, Coimbra, Portugal
2. Instituto de Tecnologia Qu铆mica e Biol贸gica, Universidade Nova de Lisboa, Av. da Rep煤blica, 2780-157, Oeiras, Portugal - ISSN：1436-2449
文摘
The features of microparticles, as size, surface structure, and morphology, depend, mainly, on the methodology used for their preparation. Emulsion polymerization techniques are undoubtedly among the most widespread. However, the use of toxic, volatile organic solvents represents a major disadvantage, namely, because of environmental issues. In this study, we prepared glutaraldehyde cross-linked chitosan鈥損oly(vinyl alcohol) microparticles by an improved water-in-oil emulsion technique using corn oil as organic phase. The application of this polymeric blend as microparticle is scarcely investigated. As resulting of the procedure here presented, spherical and smooth surface microparticles were obtained, with mean diameter of 16聽渭m. The cross-linking reaction between the aldehyde and the amino or the hydroxyl groups formed either an imine (Schiff鈥檚 base) or an acetal bond, respectively, as analyzed by infrared spectroscopy. The microparticles here described did not present cytotoxic potential. Accordingly, this study can find promising and successful application in biotechnology.