A Potential Role for Allostatic Load in Preeclampsia

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• 作者：Vanessa J. Hux ; James M. Roberts
• 关键词：Preeclampsia ; Allostatic load ; Stress ; Cardiovascular disease risk factors ; Racial disparities
• 刊名：Maternal and Child Health Journal
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：19
• 期：3
• 页码：591-597
• 全文大小：190 KB
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  16. Myrianthopo
• 刊物主题：Public Health; Sociology, general; Population Economics; Pediatrics; Gynecology; Maternal and Child Health;
• 出版者：Springer US
• ISSN：1573-6628

文摘

Preeclampsia is a multisystemic disorder of pregnancy associated with maternal and fetal complications as well as later-life cardiovascular disease. Its exact cause is not known. We developed a pregnancy-specific multisystem index score of physiologic risk and chronic stress, allostatic load (AL), early in pregnancy. Our objective was to determine whether AL measured early in pregnancy was associated with increased odds of developing preeclampsia. Data were from a single-center, prospectively collected database in a 1:2 individual-matched case control of women enrolled at 1- suggests better fit. Early pregnancy AL was higher in women with preeclampsia (1.25?±?0.68 vs. 0.83?±?0.62, p?=?0.002); women with higher AL had increasing odds of developing preeclampsia (OR 2.91, 95?% CI 1.50-.65). The difference between AIC for AL and obesity was >2 (AIC 74.4 vs. 84.4), indicating AL had a stronger association with preeclampsia. Higher allostatic load in early pregnancy is associated with increasing odds of preeclampsia. This work supports a possible role of multiple maternal systems and chronic stress early in pregnancy in the development of preeclampsia.