What is Your Risk of Contracting Alzheimer鈥檚 Disease? A Telematics Tool Helps you to Predict it

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• 作者：Rodrigo M茅ndez-Sanz ; Isabel de la Torre-D铆ez…
• 关键词：Alzheimer ; e ; Health ; Prevention ; Risk ; Web ; mobile
• 刊名：Journal of Medical Systems
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：40
• 期：1
• 全文大小：1,586 KB
• 参考文献：1.Thies, W., Alzheimer鈥檚 disease neuroimaging initiative: A decade of progress in Alzheimer鈥檚 disease. Alzheimers Dement. 11(7):727鈥?29, 2015.PubMed CrossRef
  2.De Pedro-Cuesta, J., Viru茅s-Ortega, J., Vega, S., et al., Prevalence of dementia and major dementia subtypes in Spanish populations: A reanalysis of dementia prevalence surveys, 1990鈥?008. BMC Neurol. 9:55, 2009.PubMed PubMedCentral CrossRef
  3.Castellani, R. J., and Perry, G., Pathogenesis and disease-modifying therapy in Alzheimer鈥檚 disease: The flat line of progress. Arch. Med. Res. 43(8):694鈥?98, 2012.PubMed CrossRef
  4.Della Mea, V., What is the e-health (2): The death of telemedicine? J. Med. Internet Res. 3(2):e22, 2001.PubMed PubMedCentral CrossRef
  5.da Silva Lopes, H. F., Abe, J. M., and Anghinah, R., Application of paraconsistent artificial neural networks as a method of aid in the diagnosis of Alzheimer disease. J. Med. Syst. 34(6):1073鈥?081, 2010.PubMed CrossRef
  6.Daliri, M. R., Automated diagnosis of Alzheimer disease using the scale-invariant feature transforms in magnetic resonance images. J. Med. Syst. 36(2):995鈥?000, 2012.PubMed CrossRef
  7.Ferri, C. P., Prince, M., Brayne, C., et al., Global prevalence of dementia: A Delphi consensus study. Lancet 366(9503):2112鈥?117, 2005.PubMed PubMedCentral CrossRef
  8.World Health Organization (2015) Neurological Disorders: Public Health Challenges. http://鈥媤ww.鈥媤ho.鈥媔nt/鈥媘ental_鈥媓ealth/鈥媙eurology/鈥媙eurological_鈥媎isorders_鈥媟eport_鈥媤eb.鈥媝df . Accessed 2 October 2015
  9.O鈥橞rien J., Ames D., Burns A., Dementia Second Edition: London, 2000.
  10.Bu, G., Apolipoprotein E and its receptors in Alzheimer鈥檚 disease: Pathways, pathogenesis and therapy. Nat. Rev. Neurosci. 10(5):333鈥?44, 2009.PubMed PubMedCentral CrossRef
  11.Selkoe, D. J., Alzheimer鈥檚 disease: Genes, proteins, and threrapy. Physiol. Rev. 81:741鈥?66, 2001.PubMed
  12.Levy-Lahad, E., and Dird, T. D., Genetic factors in Alzheimer鈥檚 disease: A review of recent advances. Ann. Neurol. 40(6):829鈥?40, 2004.CrossRef
  13.Li, Y. J., Scott, W. K., Hedges, D. J., Zhang, F., Gaskell, P. C., et al., Age at onset in two common degenerative diseases is genetically controlled. Am. J. Hum. Genet. 70(4):985鈥?93, 2002.PubMed PubMedCentral CrossRef
  14.Vi帽a, J., and Lloret, A., Why women have more Alzheimer鈥檚 disease than men: Gender and mitochondrial toxicity of amyloid-beta peptide. J. Alzheimers Dis. 20(Suppl 2):S527鈥?33, 2010.PubMed
  15.Alzheimer Europe (2015) Prevalence of dementia in Europe. http://鈥媤ww.鈥媋lzheimer-europe.鈥媜rg/鈥婻esearch/鈥婨uropean-Collaboration-on-Dementia/鈥婸revalence-of-dementia/鈥婸revalence-of-dementia-in-Europe . Accessed 2 October 2015
  16.Bortolon, C., Louche, A., G茅ly-Nargeot, M. C., and Raffard, S., Do patients suffering from Alzheimer鈥檚 disease present an own-age bias in face recognition? Exp. Gerontol. 70:46鈥?3, 2015.PubMed CrossRef
  17.Raggi, A., Tasca, D., Panerai, S., Neri, W., and Ferri, R., The burden of distress and related coping processes in family caregivers of patients with Alzheimer鈥檚 disease living in the community. J. Neurol. Sci. 2015. doi:10.鈥?016/鈥媕.鈥媕ns.鈥?015.鈥?8.鈥?24 .
  18.Newell, K. L., Silver, M. H., Perls, T. T. and Hedley-Whyte, E. T., What centenarians teach us about neuropathology. In: JM Martinez Lage and V Hachinski (Eds.), Envejecimiento cerebral y enfermedad. Editorial Triacastela: 31鈥?6. Madrid, Spain, 2001.
  19.Launer, L., and Hofman, A., Frequency and impact of neurologic diseases in the elderly of Europe: A collaborative study of population-based cohorts. Neurology 54(11 Suppl 5):S1鈥?, 2000.PubMed
  20.Whalley, L. J., Starr, J. M., Athawes, R., Hunter, D., Pattle, A., and Deary, I. J., Childhood mental ability and dementia. Neurology 55(10):1455鈥?459, 2000.PubMed CrossRef
  21.Larson, E. B., Dementia in the elderly: The 鈥渟ilent epidemic鈥?no more. Trans. Am. Clin. Climatol. Assoc. 112:136鈥?48, 2001.PubMed PubMedCentral
  22.Durazzo, T. C., et al., Smoking and increased Alzheimer鈥檚 disease risk: A review of potential mechanisms. Alzheimers Dement. 10(3):S122鈥揝145, 2014.PubMed PubMedCentral CrossRef
  23.Chen, R., Association of environmental tobacco smoke with dementia and Alzheimer鈥檚 disease among never smokers. Alzheimers Dement. 8(6):590鈥?95, 2012.PubMed CrossRef
  24.Brust, J. C., Ethanol and cognition: Indirect effects, neurotoxicity and neuroprotection: A review. Int. J. Environ. Res. Public Health 7(4):1540鈥?557, 2010.PubMed PubMedCentral CrossRef
  25.Del-Aguila, J. L., Koboldt, D. C., Black, K., Chasse, R., Norton, J., Wilson, R. K., and Cruchaga, C., Alzheimer鈥檚 disease: Rare variants with large effect sizes. Curr. Opin. Genet. Dev. 2015. doi:10.鈥?016/鈥媕.鈥媑de.鈥?015.鈥?7.鈥?08 .PubMed
  26.Xu, W., Tan, L., Wang, H. F., Jiang, T., Tan, M. S., Tan, L., Zhao, Q. F., Li, J. Q., Wang, J., and Yu, J. T., Meta-analysis of modifiable risk factors for Alzheimer鈥檚 disease. J. Neurol. Neurosurg. Psychiatry, 2015. doi:10.鈥?136/鈥媕nnp-2015-310548 .
  27.Lu, F. P., Lin, K. P., and Kuo, H. K., Diabetes and the risk of multi-system aging phenotypes: A systematic review and meta-analysis. PLoS One 4(1):e4144, 2009.PubMed PubMedCentral CrossRef
  28.R枚nnemaa, E., Zethelius, B., et al., Glucose metabolism and the risk of Alzheimer鈥檚 disease and dementia: A population-based 12 year follow-up study in 71-year-old men. Diabetologia 52(8):1504鈥?510, 2009.PubMed CrossRef
  
• 作者单位：Rodrigo M茅ndez-Sanz (1)
  Isabel de la Torre-D铆ez (1)
  Miguel L贸pez-Coronado (1)
  
  1. Department of Signal Theory and Communications, and Telematics Engineering, University of Valladolid, Paseo de Bel茅n, 15, 47011, Valladolid, Spain
  
• 刊物类别：Mathematics and Statistics
• 刊物主题：Statistics
  Statistics for Life Sciences, Medicine and Health Sciences
  Health Informatics and Administration
  
• 出版者：Springer Netherlands
• ISSN：1573-689X

文摘

Alzheimer鈥檚 disease (AD) is the most common dementia in developed countries. Between the identified risk factors, one of the most important is the age. Its prevalence reaches 24 % in men and 33 % in women over 85 years. Increase in life expectancy, making it a serious public health problem. Prevention of Alzheimer鈥檚 disease represents a major challenge to health. Given that Alzheimer鈥檚 disease is largely dependent on the genetics of each person and uninterrupted progress of the age, which is try to make people aware that there are other factors that can alter your chance of developing the Alzheimer disease and although currently not reduce, help is not increased in the near or distant future. The aim of this paper is to develop and evaluate a Web-Mobile application (Alzhe Alert) used to calculate the risk of Alzheimer鈥檚 from a short questionnaire using a computer or mobile device, so that any user, without requiring computer skills, can access the website to estimate their risk of developing the disease in the coming years depending on their habits and daily basis activities. The users who have realized the questionnaire can to observe in a graph the result, and they will know which is at risk for Alzheimer鈥檚 at present and over the next 50 years if they continue with the same habits and lifestyle. The objective is that the users can be aware of the risk they have different habits of life about their health. Currently, 243 users (84 women and 159 men) of white race have completed the questionnaire. 76 % of the users have got a risk below the average. Keywords Alzheimer e-Health Prevention Risk Web-mobile