Hepatic Enzyme’s Reference Intervals and Their Modulating Factors in Western Indian Population

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• 作者：Shalini N. Maksane ; Sucheta P. Dandekar…
• 关键词：Liver enzymes ; Body mass index ; Waist ; hip ratio ; Alanine aminotransferase ; Aspartate aminotransferase ; Gamma glutamyl transferase
• 刊名：Indian Journal of Clinical Biochemistry
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：31
• 期：1
• 页码：108-116
• 全文大小：858 KB
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• 作者单位：Shalini N. Maksane (1)
  Sucheta P. Dandekar (1)
  Akash Shukla (2)
  Shobna Bhatia (2)
  
  1. Department of Biochemistry, Seth G. S. Medical College & K. E. M. Hospital, Parel, Mumbai, 400012, Maharashtra, India
  2. Department of Gastroenterology, Seth G. S. Medical College, Mumbai, India
  
• 刊物主题：Biochemistry, general; Microbiology; Chemistry/Food Science, general; Pathology;
• 出版者：Springer India
• ISSN：0974-0422

文摘

The reference intervals (RIs) of serum aminotransferases and Gamma-glutamyl transferase (GGT) have been established many years ago. Recent RIs are not available. The prospective study was conducted to re-evaluate the RIs of liver enzymes and the effect of demographic and anthropometric variables on them in western Indian population. A total of 1059 blood donors comprised the study population. Anthropometry and serum liver enzymes levels were measured. Subjects were categorized into normal weight and overweight by using body mass index (BMI) and waist circumference (WC). For RI determination, non-parametric methodology recommended by IFCC/CLSI was adopted. Mann–Whitney test and Spearman’s rank correlation were used for statistical analysis. Upper limit of normal reference value of liver enzymes were lower in female compared to male. (ALT—23.55 F vs 36.00 M, GGT—34.58 F vs 36.20 M) When RI of liver enzymes were calculated according to body mass index, the upper limit of normal of ALT and GGT were higher in overweight group compared to normal weight group. (ALT—38.00 vs 27.00 IU/L and GGT—37.59 vs 35.26 IU/L). In both male and female, liver enzymes correlated significantly with age. WC and BMI were positively correlated with AST, ALT and GGT in both subgroups and the correlation was stronger in male. Demographic factors should be considered for making liver enzyme tests more clinically relevant. Gender based partitioning should be adopted for serum alanine aminotransferase (ALT) and GGT reference values for Western Indian population. Keywords Liver enzymes Body mass index Waist-hip ratio Alanine aminotransferase Aspartate aminotransferase Gamma glutamyl transferase