Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide
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- 作者：Jaques A. Courtade ; Evan Y. Wang ; Paul Yen ; Derek L. Dai…
- 关键词：Beta cell ; Islet amyloid ; Islet transplant ; Prohormone processing
- 刊名：Diabetologia
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：60
- 期：3
- 页码：453-463
- 全文大小：2010KB
- 刊物类别：Medicine
- 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0428
- 卷排序：60
文摘
Aims/hypothesisA contributor to beta cell failure in type 2 diabetes and islet transplants is amyloid formation by aggregation of the beta cell peptide, islet amyloid polypeptide (IAPP). Similar to the proinsulin processing pathway that generates insulin, IAPP is derived from a prohormone precursor, proIAPP, which requires cleavage by prohormone convertase (PC) 1/3 and PC2 in rodent pancreatic beta cells. We hypothesised that loss of PC2 would promote beta cell death and dysfunction in a rodent model of human beta cell proIAPP overexpression.