Pharmacological investigation on the anti-oxidant and anti-inflammatory activity of N-acetylcysteine in an ex vivo model of COPD exacerbation

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• 作者：Mario Cazzola ; Luigino Calzetta ; Francesco Facciolo ; Paola Rogliani…
• 关键词：Anti ; inflammatory effect ; Anti ; oxidant effect ; COPD ; Lipopolysaccharide ; N ; acetylcysteine
• 刊名：Respiratory Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：1075KB
• 刊物主题：Pneumology/Respiratory System;
• 出版者：BioMed Central
• ISSN：1465-993X
• 卷排序：18

文摘

BackgroundOxidative stress is recognized to be one of predisposing factor in the pathogenesis of COPD. The oxidant/antioxidant imbalance is significantly pronounced in patients with COPD exacerbation. N-acetylcysteine (NAC) seems to be able to reduce COPD exacerbations by modulating the oxidative stress in addition to its well-known mucolytic activity, but there are discordant findings on the actual anti-oxidant activity of NAC.