BAP1 dependent expression of long non-coding RNA NEAT-1 contributes to sensitivity to gemcitabine in cholangiocarcinoma
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- 作者：Mansi Parasramka ; Irene K. Yan ; Xue Wang ; Phuong Nguyen ; Akiko Matsuda…
- 关键词：Cholangiocarcinoma ; LncRNA ; BAP1 ; NEAT ; 1 ; Gemcitabine ; Cisplatin ; Combination therapy
- 刊名：Molecular Cancer
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1157KB
- 刊物主题：Cancer Research; Oncology;
- 出版者：BioMed Central
- ISSN：1476-4598
- 卷排序：16
文摘
BackgroundGenetic alterations in chromatin modulators such as BRCA-1 associated protein-1 (BAP1) are the most frequent genetic alteration in intrahepatic cholangiocarcinomas (CCA). We evaluated the contribution of BAP1 expression on tumor cell behavior and therapeutic sensitivity to identify rationale therapeutic strategies.