EPA attenuates ultraviolet radiation-induced downregulation of aquaporin-3 in human keratinocytes

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• 作者：Byoung-Kook Jeon ; Moon-Kyung Kang ; Ghang-Tai Lee…
• 关键词：Aquaporin ; 3 ; EPA ; UVB ; ERK activation ; Human keratinocyte
• 刊名：Archives of Pharmacal Research
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：38
• 期：8
• 页码：1552-1560
• 全文大小：1,219 KB
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• 作者单位：Byoung-Kook Jeon (1)
  Moon-Kyung Kang (2)
  Ghang-Tai Lee (3)
  Kun-Kuk Lee (3)
  Ho-Sub Lee (1)
  Won-Hong Woo (2)
  Yeun-Ja Mun (1)
  
  1. BK21-plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, 570-749, Jeollabukdo, Republic of Korea
  2. Department of Anatomy, College of Oriental Medicine, Wonkwang University, Iksan, 570-749, Korea
  3. Coreana Cosmetics, R&D Center, Cheonan, 330-833, Korea
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid (ω-3 PUFA) that protects against photodamage and photocarcinogenesis in mammals. Aquaporin-3 (AQP3) is a water/glycerol transport protein that is found in basal layer keratinocytes. In this study, we have investigated the protective effect of EPA against ultraviolet B (UVB)-induced AQP3 downregulation in human keratinocytes. EPA treatment was found to increase AQP3 gene and protein expression in human epidermal keratinocytes (HaCaT). Using a specific inhibitor, we observed that the effect of EPA on AQP3 expression was mediated by extracellular signal-regulated kinase (ERK) activation. UVB radiation induced AQP3 downregulation in HaCaT cells, and it was found that EPA treatment attenuated UVB-induced AQP3 reduction and the associated cell death. UVB-induced downregulation of AQP3 was blocked by EPA and p38 inhibitor SB203580. Collectively, the present results show that EPA increased AQP3 expression and that this led to a reduction UVB-induced photodamage.