Synthesis of some novel substituted phenylisoxazol phenoxy 2-methylpropanoic acids and there in vivo hypolipidemic activity

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• 作者：Santosh N. Mokale ; Pritam N. Dube ; Manjusha C. Nevase…
• 关键词：Hyperlipidemia ; Phenoxy propanoic acid ; Isoxazole ; Atherogenic index
• 刊名：Medicinal Chemistry Research
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：25
• 期：3
• 页码：422-428
• 全文大小：824 KB
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• 作者单位：Santosh N. Mokale (1)
  Pritam N. Dube (1)
  Manjusha C. Nevase (1)
  Nikhil S. Sakle (1)
  Vishakha R. Shelke (1)
  Swati A. Bhavale (1)
  Afreen Begum (1)
  
  1. Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, 431001, India
  
• 刊物主题：Pharmacology/Toxicology; Biochemistry, general; Cell Biology;
• 出版者：Springer US
• ISSN：1554-8120

文摘

The novel series of phenylisoxazol phenoxy 2-methylpropanoic acid derivatives were synthesized and evaluated for their in vivo hypolipidemic activity by triton WR-1339-induced hyperlipidemia in rats. The newly synthesized compounds 5a and 5i showed significant decrease in the serum TCH, TG, LDL and VLDL along with an increase in serum HDL levels as compared to standard drug Fenofibrate. The treated groups also showed significant decrease in the atherogenic index, TC:HDL risk ratios compared to cholesterol-induced hyperlipidemic control group. These molecules indeed have the potential to be developed as antihypolipidemic molecules. Keywords Hyperlipidemia Phenoxy propanoic acid Isoxazole Atherogenic index