Mobitz type I and II atrioventricular blocks during fingolimod therapy

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• 作者：Francesco Saccà ; Giorgia Puorro ; Angela Marsili ; Chiara Pane…
• 刊名：Neurological Sciences
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：37
• 期：9
• 页码：1557-1559
• 全文大小：313 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Neuroradiology
  Neurosurgery
  Psychiatry
  
• 出版者：Springer Milan
• ISSN：1590-3478
• 卷排序：37

文摘

We investigated patients who showed a second-degree atrioventricular block (S-AVB) after the first fingolimod administration. We observed six patients with S-AVB, three Mobitz type I, and three type II. Monitoring continued on the second day for all patients. Three patients showed persistence of the S-AVB, with resolution on the second or third day. One patient had a persistent S-AVB up to the fourth day when fingolimod was discontinued. We conclude that Mobitz type II S-AVB is possible during fingolimod therapy. Patients with S-AVB could be monitored until resolution of the S-AVBs, as these may persist several days after the first fingolimod administration.KeywordsMultiple sclerosisRelapsingFingolimodTreatmentAtrioventricular blockCardiac safetyTolerabilityMobitz type II