Simultaneous carotid PET/MR: feasibility and improvement of magnetic resonance-based attenuation correction
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- 作者：Jason Bini ; Mootaz Eldib ; Philip M. Robson…
- 关键词：PET/MR ; Attenuation correction ; Dixon ; Ultrashort echo time ; Carotid arteries
- 刊名：The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging)
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：32
- 期：1
- 页码：61-71
- 全文大小：2,325 KB
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Mootaz Eldib (1) (2)
Philip M. Robson (1) (3)
Claudia Calcagno (1) (3)
Zahi A. Fayad (1) (3) (4)
1. Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, P. O. Box 1234, New York, NY, 10029, USA
2. Department of Biomedical Engineering, The City College of New York, New York, NY, USA
3. Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
4. Department of Cardiology, Zena and Michael A. Weiner Cardiovascular Institute and Marie-Josée and Henry R. Kravis Cardiovascular Health Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Cardiology - 出版者：Springer Netherlands
- ISSN：1573-0743
文摘
Errors in quantification of carotid positron emission tomography (PET) in simultaneous PET/magnetic resonance (PET/MR) imaging when not incorporating bone in MR-based attenuation correction (MRAC) maps, and possible solutions, remain to be fully explored. In this study, we demonstrated techniques to improve carotid vascular PET/MR quantification by adding a bone tissue compartment to MRAC maps and deriving continuous Dixon-based MRAC (MRACCD) maps. We demonstrated the feasibility of applying ultrashort echo time-based bone segmentation and generation of continuous Dixon MRAC to improve PET quantification on five subjects. We examined four different MRAC maps: system standard PET/MR MRAC map (air, lung, fat, soft tissue) (MRACPET/MR), standard PET/MR MRAC map with bone (air, lung, fat, soft tissue, bone) (MRACPET/MRUTE), MRACCD map (no bone) and continuous Dixon-based MRAC map with bone (MRACCDUTE). The same PET emission data was then reconstructed with each respective MRAC map and a CTAC map (PETPET/MR, PETPET/MRUTE, PETCD, PECDUTE) to assess effects of the different attenuation maps on PET quantification in the carotid arteries and neighboring tissues. Quantitative comparison of MRAC attenuation values for each method compared to CTAC showed small differences in the carotid arteries with UTE-based segmentation of bone included and/or continuous Dixon MRAC; however, there was very good correlation for all methods in the voxel-by-voxel comparison. ROI-based analysis showed a similar trend in the carotid arteries with the lowest correlation to PETCTAC being PETPETMR and the highest correlation to PETCTAC being PETCDUTE. We have demonstrated the feasibility of applying UTE-based segmentation and continuous Dixon MRAC maps to improve carotid PET/MR vascular quantification. Keywords PET/MR Attenuation correction Dixon Ultrashort echo time Carotid arteries