Novel immunoregulatory role of perforin-positive dendritic cells
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- 作者：Ran Orgad ; Bar Nathansohn-Levi ; Sivan Kagan…
- 关键词：Dendritic cells ; Perforin ; Metabolic syndrome ; Autoimmunity
- 刊名：Seminars in Immunopathology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：39
- 期：2
- 页码：121-133
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Immunology; Internal Medicine;
- 出版者：Springer Berlin Heidelberg
- ISSN：1863-2300
- 卷排序：39
文摘
The recently described generation of a highly defined population of dendritic cells which express perforin and granzyme A (termed “perf-DCs”) and their ability to selectively delete cognate CD8+ T cell has raised the possibility that these cells play a role in the maintenance of peripheral tolerance. Using bone marrow transplantation, we generated mice selectively lacking perforin expressing dendritic cells. These mice progressively gain weight and exhibit features resembling metabolic syndrome as well as an enhanced susceptibility to autoimmunity induction. Interestingly, these pathological phenotypes were reversed upon treatment with CD4/CD8 neutralizing antibodies. Thus, it appears that this rare subpopulation of dendritic cells (perf-DCs) displays a major regulatory role in adipose tissue inflammatory processes and in autoimmunity.