A numerical design study of chaotic mixing of magnetic particles in a microfluidic bio-separator

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• 作者：M. Zolgharni ; S. M. Azimi ; M. R. Bahmanyar and W. Balachandran
• 关键词：Magnetic particles ; Chaotic mixing ; Microfluidics ; Numerical
• 刊名：Microfluidics and Nanofluidics
• 出版年：2007
• 出版时间：December, 2007
• 年：2007
• 卷：3
• 期：6
• 页码：677-687
• 全文大小：487 KB
• 刊物类别：Engineering
• 刊物主题：Engineering Fluid Dynamics
  Medical Microbiology
  Polymer Sciences
  Nanotechnology
  Mechanics, Fluids and Thermodynamics
  Engineering Thermodynamics and Transport Phenomena
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1613-4990

文摘

A two-dimensional numerical investigation into the mixing of magnetic microparticles with bio-cells in a chaotic micromixer is carried out by using a multiphysics finite element analysis package. Fluid and magnetic problems are simulated in steady-state and time-dependent modes, respectively. Intensity of segregation is utilized as the main index to examine the efficiency of the mixer. Trajectories of the particles are used in order to detect chaos in their motion and quantify its extent. Moreover, probability of the collision between particles and target bio-cells is examined as a supplemental index to study the effects of driving parameters on the mixing process. Simulation results reveal that while in some ranges of operating conditions all indices are in good agreement, there are some ranges where they appear to predict contradicting results which is discussed in details. It is found that optimum operating conditions for the system is obtained when the Strouhal number is less than 0.6, which corresponds to the efficiency of about 85% in a mixing length of 500 μm (The mixer design described here is patent pending).