Association of ADAM33 gene with susceptibility to COPD in Tibetan population of China

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• 作者：Jinling Xiao (1) xiaojinlingxiao@yahoo.com.cn
  Jianyu Han (2) doctorhanjianyu@yahoo.com.cn
  Xinyan Wang (1) wxylyfll@163.com
  Demi Hua (3) huademi@yahoo.com
  Dongju Su (1) sudongju@yahoo.com.cn
  Yongxia Bao (1) baoyongxia@126.com
  Fuzhen Lv (1) Redcrossing_xiao@163.com
• 关键词：ADAM33 gene – ; COPD – ; Tibetan population of China
• 刊名：Molecular Biology Reports
• 出版年：2011
• 出版时间：November 2011
• 年：2011
• 卷：38
• 期：8
• 页码：4941-4945
• 全文大小：1.6 MB
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• 作者单位：1. Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081 China2. Department of Plastic and Aesthetic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150081 China3. Department of Respiratory, The Second People鈥檚 Hospital of Tibet, Lasa, Tibet, China
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Animal Anatomy, Morphology and Histology
  Animal Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-4978

文摘

Chronic obstructive pulmonary disease (COPD) is a common, complex disorder associated with substantial morbidity and mortality, influenced by both environmental factor and genetic factor. ADAM33 gene was found to be associated with asthma, declined lung function and COPD. The purpose of the study was to test whether SNPs in ADAM33 were associated with COPD in Tibetan population of China. Polymerase chain reaction-restriction fragment length polymorphism was carried out to genotype the eight SNPs (V4, T2, T1, S2, S1, Q-1 and F + 1) of ADAM33 on 240 COPD patients and 221 healthy individuals. Four SNPs (V4, T2, T1 and S1) and four haplotypes (H2 CGAAGAGC, H5 GAGAGAGC, H9 GAAAGAGC and H6 CGGGGAGC of ADAM33 gene were associated with COPD significantly (defined as P < 0.05). The results indicate that there is an association between ADAM33 polymorphisms and COPD in Tibetan population of China.