Multilevel control of glucose homeostasis by adenylyl cyclase 8

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• 作者：Matthieu Raoux (1) (2)
  Pierre Vacher (2) (3)
  Julien Papin (1) (4)
  Alexandre Picard (5)
  Elzbieta Kostrzewa (6)
  Anne Devin (2) (7)
  Julien Gaitan (1) (2)
  Isabelle Limon (8)
  Martien J. Kas (6)
  Christophe Magnan (5)
  Jochen Lang (1) (2)
  
  1. Universit茅 de Bordeaux ; CNRS UMR 5248 ; Chimie et Biologie des Membranes et Nano-objets ; Batiment B14 ; All茅e Geoffrey St Hilaire ; CS90063 ; F-33615 ; Pessac ; France
  2. Universit茅 de Bordeaux ; Bordeaux ; France
  3. Inserm Unit茅 U 916 ; Institut Bergoni茅 ; Bordeaux ; France
  4. Laboratoire de Pharmacodynamie et de Th茅rapeutique ; Facult茅 de M茅decine ; Universit茅 Libre de Bruxelles ; Bruxelles ; Belgium
  5. BFA-Unit茅 de Biologie Fonctionnelle et Adaptative鈥揢MR CNRS 8251 ; Universit茅 Paris-Diderot ; Paris ; France
  6. Department of Translational Neuroscience ; Brain Center Rudolf Magnus ; University Medical Centre Utrecht ; Utrecht ; the Netherlands
  7. Institut de Biochimie et G茅n茅tique Cellulaires ; UMR CNRS 5095 ; Bordeaux ; France
  8. Universit茅 Pierre et Marie Curie ; UR4 Aging ; Stress and Inflammation ; Paris ; France
  
• 关键词：Adenylyl cyclase ; Diabetes ; Glucose homeostasis ; Insulin secretion ; Intracellular calcium ; Islets of Langerhans
• 刊名：Diabetologia
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：58
• 期：4
• 页码：749-757
• 全文大小：478 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Nutrient homeostasis requires integration of signals generated by glucose metabolism and hormones. Expression of the calcium-stimulated adenylyl cyclase ADCY8 is regulated by glucose and the enzyme is capable of integrating signals from multiple pathways. It may thus have an important role in glucose-induced signalling and glucose homeostasis. Methods We used pharmacological and genetic approaches in beta cells to determine secretion and calcium metabolism. Furthermore, Adcy8 knockout mice were characterised. Results In clonal beta cells, inhibitors of adenylyl cyclases or their downstream targets reduced the glucose-induced increase in cytosolic calcium and insulin secretion. This was reproduced by knock-down of ADCY8, but not of ADCY1. These agents also inhibited glucose-induced increase in cytosolic calcium and electrical activity in primary beta cells and similar effects were observed after ADCY8 knock-down. Moreover, insulin secretion was diminished in islets from Adcy8 knockout mice. These mice were glucose intolerant after oral or intraperitoneal administration of glucose whereas their levels of glucagon-like peptide-1 remained unaltered. Finally, we knocked down ADCY8 in the ventromedial hypothalamus to evaluate the need for ADCY8 in the central regulation of glucose homeostasis. Whereas mice fed a standard diet had normal glucose levels, high-fat diet exacerbated glucose intolerance and knock-down mice were incapable of raising their plasma insulin levels. Finally we confirmed that ADCY8 is expressed in human islets. Conclusions/interpretations Collectively, our findings demonstrate that ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion.