Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer

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• 作者：Xinwei Cheng ; Qibing Liu ; Hong Li ; Chen Kang ; Yang Liu…
• 关键词：KEY WORDSantisense oligonucleotide ; bcl ; 2 ; cancer ; drug delivery ; lipid nanoparticles
• 刊名：Pharmaceutical Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：34
• 期：2
• 页码：310-320
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering;
• 出版者：Springer US
• ISSN：1573-904X
• 卷排序：34

文摘

PurposeBcl-2 is an anti-apoptotic gene that is frequently overexpressed in human cancers. G3139 is an antisense oligonucleotide against bcl-2 that has shown limited efficacy in clinical trials. Here, we report the synthesis of a new antisense oligonucleotide containing additional chemical modifications and its delivery using nanoparticles.