Studies on the role of dopamine D1 receptors in the development and expression of MDMA-induced behavioral sensitization in rats

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• 作者：María Ramos ; Beatriz Go?i-Allo and Norberto Aguirre
• 关键词：3 ; 4 ; methylenedioxyamphetamine (MDMA ecstasy) ; D1 receptor ; Behavioral sensitization ; Nucleus accumbens ; Medial prefrontal cortex ; SCH 23390
• 刊名：Psychopharmacology
• 出版年：2004
• 出版时间：December 2004
• 年：2004
• 卷：177
• 期：1-2
• 页码：100-110
• 全文大小：380 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale There is a large body of evidence indicating that the mesoaccumbens dopamine pathway is critically involved in the expression of behavioral sensitization to amphetamine and cocaine, but its role in the development of sensitization to psychostimulants is not that sound. Very few studies, however, have examined the role of dopamine transmission in 3,4-methylenedioxymethamphetamine (MDMA)-induced sensitization.