What is a gene for?

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• 作者：Lindell Bromham
• 关键词：Bioinformatics ; Mutation ; Heredity ; Evolution ; Genetics
• 刊名：Biology & Philosophy
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：31
• 期：1
• 页码：103-123
• 全文大小：457 KB
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• 作者单位：Lindell Bromham (1)
  
  1. Macreovolution and Macroecology, Evolution Ecology and Genetics, Research School of Biology, Australian National University, Canberra, ACT, 0200, Australia
  
• 刊物类别：Humanities, Social Sciences and Law
• 刊物主题：Philosophy
  Philosophy of Biology
  Evolutionary Biology
  
• 出版者：Springer Netherlands
• ISSN：1572-8404

文摘

The word “gene” means different things to different people, and can even be used in multiple ways by the same individual. In this review, I follow a particular thread running through Griffith and Stotz’s “Genetics and Philosophy: an introduction”, which is the way that methods of investigation influence the way we define the concept of “gene”, from nineteen century breeding experiments to twenty-first century big data bioinformatics. These different views lead to a set of gene concepts, which only partially overlap each other, each of which picks up on a different part of gene behaviour, function or scientific utility. This plurality of concepts carries over to the use of the concept of “information” in biology, where the non-overlapping concepts can be connected to whether you view the genome as a blueprint for development, a response to environmental triggers, an engine of heritability, or a document of history. Keywords Bioinformatics Mutation Heredity Evolution Genetics