The allosteric modulation of lipases and its possible biological relevance
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- 作者：Jens K?hler (1)
Bernhard Wünsch (1) - 刊名：Theoretical Biology and Medical Modelling
- 出版年：2007
- 出版时间：December 2007
- 年：2007
- 卷：4
- 期：1
- 全文大小：564KB
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Bernhard Wünsch (1)
1. Institut für Pharmazeutische und Medizinische Chemie, Westf?lische Wilhelms-Universit?t Münster, Hittorfstra?e 58-62, D-48149, Münster, Germany - ISSN：1742-4682
文摘
Background During the development of an enantioselective synthesis using the lipase from Mucor miehei an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown. Theory Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism. Conclusion This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity.